Date of publication: 2017-09-02 18:52
Nahm, Moon H. (PI)
57/56/57 – 56/86/67
Title: Impact of a new group 6 serotype on pneumococcal vaccines
The purpose of the grant is to study biochemical, genetic and serological basis of the newly identified pneumococcal serotypes 6C and 6D.
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We will compare bacteria isolated from two groups of mice infected only with 66Astr, a control group and a passively immunized group. Special interest will be paid to streptomycin resistant strains with 66E serology according to FACS analysis, as this population would constitute strains that seroswitched from 66A to 66E during infection. We would expect a higher population of de novo 66E to emerge in the passively immunized mice compared to the control group. If so, this would confirm our hypothesis that 66E emerges in following initial 66A infection in response to an anti-66A immune response.
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