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Smalls-Mantey, Sample F31 Application and Summary

Date of publication: 2017-09-02 18:52

R56-AI-86978
NIH/NIAID 
Nahm, Moon H. (PI) 
57/56/57 – 56/86/67
Title:  Impact of a new group 6 serotype on pneumococcal vaccines
The purpose of the grant is to study biochemical, genetic and serological basis of the newly identified pneumococcal serotypes 6C and 6D.
Role:  PI

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We will compare bacteria isolated from two groups of mice infected only with 66Astr, a control group and a passively immunized group. Special interest will be paid to streptomycin resistant strains with 66E serology according to FACS analysis, as this population would constitute strains that seroswitched from 66A to 66E during infection. We would expect a higher population of de novo 66E to emerge in the passively immunized mice compared to the control group. If so, this would confirm our hypothesis that 66E emerges in following initial 66A infection in response to an anti-66A immune response. 

[Our Web version of this sample application can't reproduce the layout of the actual PDF forms. The attachments are included below. In the original version, these attachments met the page limits.]

Currently HIV-specific ADCC is considered one of the very top priorities in the field of HIV-specific immunity. Our laboratory has assembled the best techniques and reagents in the field to carry out this project. We have extensive experience in HIV-specific antibodies and cytotoxicity. In addition we have a long track record of training students to prepare them for a carreer in biomedical research. 

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